Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function.

@article{Ito2010MesenchymalSC,
  title={Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function.},
  author={Taihei Ito and Shin Itakura and Ivan Todorov and Jeffrey S Rawson and Sadaki Asari and Jonathan Shintaku and Indu Nair and Kevin Ferreri and Fouad Kandeel and Yoko S Mullen},
  journal={Transplantation},
  year={2010},
  volume={89 12},
  pages={1438-45}
}
BACKGROUND Bone marrow-derived mesenchymal stem cells (MSCs) are known to produce vascular endothelial growth factor. We hypothesize that co-transplantation of MSCs and islets promotes revascularization and improves islet graft function. METHODS Lewis rat islets were infused into the liver of streptozotocin-diabetic syngeneic recipients or transplanted under the renal capsule of nonobese diabetic severe combined immunodeficiency (NOD SCID) mice with MSCs isolated from Lewis bone marrow and… CONTINUE READING
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