Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices.

@article{Ascheim2014MesenchymalPC,
  title={Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices.},
  author={Deborah D. Ascheim and Annetine Christine Gelijns and Daniel J. Goldstein and Lemuel A. Moye and Nicholas Gerard Smedira and Sangjin S Lee and Charles T. Klodell and Anita D Szady and Michael K. Parides and Neal O. Jeffries and D. W. Skerrett and Doris A Taylor and Jesus Eduardo Rame and Carmelo A. Milano and J. G. Rogers and Janine Lynch and Todd M. Dewey and Eric J. Eichhorn and Benjamin Chih-An Sun and David S. Feldman and Robert D. Simari and Patrick T O'gara and Wendy C. Taddei-Peters and Marissa A. Miller and Yoshifumi Naka and E Bagiella and E. A. Rose and Yiping Joseph Woo},
  journal={Circulation},
  year={2014},
  volume={129 22},
  pages={
          2287-96
        }
}
BACKGROUND Allogeneic mesenchymal precursor cells (MPCs) injected during left ventricular assist device (LVAD) implantation may contribute to myocardial recovery. This trial explores the safety and efficacy of this strategy. METHODS AND RESULTS In this multicenter, double-blind, sham-procedure controlled trial, 30 patients were randomized (2:1) to intramyocardial injection of 25 million MPCs or medium during LVAD implantation. The primary safety end point was incidence of infectious… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

HeartWare ventricular assist system for bridge to transplant: combined results of the bridge to transplant and continued access protocol trial.

  • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • 2013

Mesenchymal stem cells induce T - cell tolerance and protect the preterm brain after global hypoxia - ischemia

RK Jellema, TG Wolfs, +10 authors BW Kramer
  • PLoS One
  • 2013

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