Mesenchymal-endothelial-transition contributes to cardiac neovascularization

  title={Mesenchymal-endothelial-transition contributes to cardiac neovascularization},
  author={Eric Ubil and Jinzhu Duan and Indulekha C. L. Pillai and Manuel Rosa-Garrido and Yong Wu and Francesca Bargiacchi and Yan Lu and Seta Stanbouly and Jie Huang and Mauricio Rojas and Thomas M. Vondriska and Enrico Stefani and Arjun Deb},
Endothelial cells contribute to a subset of cardiac fibroblasts by undergoing endothelial-to-mesenchymal transition, but whether cardiac fibroblasts can adopt an endothelial cell fate and directly contribute to neovascularization after cardiac injury is not known. Here, using genetic fate map techniques, we demonstrate that cardiac fibroblasts rapidly adopt an endothelial-cell-like phenotype after acute ischaemic cardiac injury. Fibroblast-derived endothelial cells exhibit anatomical and… CONTINUE READING
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