Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury.

@article{Moore2019MesenchymalDE,
  title={Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury.},
  author={Tara L Moore and Monica A. Pessina and Bethany G. E. Bowley and Samantha M Calderazzo and Maria Medalla and Venan Go and Zishu Zhang and Mika{\"e}l Chopp and Steven Finklestein and Allen G. Harbaugh and Douglas L. Rosene and Ben Buller},
  journal={Restorative neurology and neuroscience},
  year={2019}
}
BACKGROUND Exosomes from mesenchymal stromal cells (MSCs) are endosome-derived vesicles that have been shown to enhance functional recovery in rodent models of stroke. OBJECTIVE Building on these findings, we tested exosomes as a treatment in monkeys with cortical injury. METHODS After being trained on a task of fine motor function of the hand, monkeys received a cortical injury to the hand representation in primary motor cortex. Twenty-four hours later and again 14 days after injury… CONTINUE READING