Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.

Abstract

The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells. Here we demonstrate that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component. Nestin(+) MSCs contain all the bone… (More)
DOI: 10.1038/nature09262

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Cite this paper

@article{MndezFerrer2010MesenchymalAH, title={Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.}, author={Sim{\'o}n M{\'e}ndez-Ferrer and Tatyana V Michurina and Francesca Ferraro and Amin R. Mazloom and Ben D. MacArthur and S{\'e}rgio A. Lira and David T Scadden and Avi Ma'ayan and Grigori Enikolopov and Paul S Frenette}, journal={Nature}, year={2010}, volume={466 7308}, pages={829-34} }