Mesenchymal Stromal Cells are Readily Recoverable from Lung Tissue, but not the Alveolar Space, in Healthy Humans.

@article{Sinclair2016MesenchymalSC,
  title={Mesenchymal Stromal Cells are Readily Recoverable from Lung Tissue, but not the Alveolar Space, in Healthy Humans.},
  author={Kenneth Andrew Sinclair and Stephanie T Yerkovich and Taiping Chen and Jonathan L. McQualter and Peter M. A. Hopkins and Christine A. Wells and Daniel C Chambers},
  journal={Stem cells},
  year={2016},
  volume={34 10},
  pages={2548-2558}
}
Stromal support is critical for lung homeostasis and the maintenance of an effective epithelial barrier. Despite this, previous studies have found a positive association between the number of mesenchymal stromal cells (MSCs) isolated from the alveolar compartment and human lung diseases associated with epithelial dysfunction. We hypothesised that bronchoalveolar lavage derived MSCs (BAL-MSCs) are dysfunctional and distinct from resident lung tissue MSCs (LT-MSCs). In this study, we… CONTINUE READING
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