Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation

  title={Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation},
  author={Y R Kuo and Chien-Chang Chen and Shigeru Goto and Pao-Yuan Lin and Fu-Chan Wei and C L Chen},
  booktitle={Clinical & developmental immunology},
Vascularized composite allotransplantations (VCAs) are not routinely performed for tissue reconstruction because of the potentially harmful adverse effects associated with lifelong administration of immunosuppressive agents. Researchers have been eagerly seeking alternative methods that circumvent the long-term use of immunosuppressants. Mesenchymal stem cells (MSCs) show promise as an immunomodulatory therapeutic agent and are currently being tested in preclinical and clinical settings as… CONTINUE READING


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