Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells

@inproceedings{Klopp2010MesenchymalSC,
  title={Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells},
  author={Ann Hoge Klopp and L. Lacerda and Anshul Gupta and Bisrat G Debeb and Travis N. Solley and Li Li and Erika L Spaeth and Wei Xu and Xiaomei Zhang and Michael T. Lewis and James M. Reuben and Savitri Krishnamurthy and Mauro Ferrari and Rog{\'e}rio S Gaspar and Thomas A. Buchholz and Massimo Cristofanilli and Frank C. Marini and Michael Andreeff and Wendy A Woodward},
  booktitle={PloS one},
  year={2010}
}
INTRODUCTION Normal and malignant breast tissue contains a rare population of multi-potent cells with the capacity to self-renew, referred to as stem cells, or tumor initiating cells (TIC). These cells can be enriched by growth as "mammospheres" in three-dimensional cultures. OBJECTIVE We tested the hypothesis that human bone-marrow derived mesenchymal stem cells (MSC), which are known to support tumor growth and metastasis, increase mammosphere formation. RESULTS We found that MSC… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…