Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke

@inproceedings{Nakajima2017MesenchymalSC,
  title={Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke},
  author={Masataka Nakajima and Chikako Nito and Kota Sowa and Satoshi Suda and Yasuhiro Nishiyama and Aki Nakamura-Takahashi and Yuko Nitahara-Kasahara and Kiwamu Imagawa and Tohru Hirato and Masayuki Ueda and Kazumi Kimura and Takashi Okada},
  booktitle={Molecular therapy. Methods & clinical development},
  year={2017}
}
Interleukin (IL)-10 is a contributing factor to neuroprotection of mesenchymal stem cell (MSC) transplantation after ischemic stroke. Our aim was to increase therapeutic effects by combining MSCs and ex vivo IL-10 gene transfer with an adeno-associated virus (AAV) vector using a rat transient middle cerebral artery occlusion (MCAO) model. Sprague-Dawley… CONTINUE READING