Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis

  title={Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis},
  author={Yaojiong Wu and Liwen Chen and Paul G. Scott and Edward E. Tredget},
  journal={STEM CELLS},
Although chronic wounds are common, treatment for these disabling conditions remains limited and largely ineffective. In this study, we examined the benefit of bone marrow‐derived mesenchymal stem cells (BM‐MSCs) in wound healing. Using an excisional wound splinting model, we showed that injection around the wound and application to the wound bed of green fluorescence protein (GFP)+ allogeneic BM‐MSCs significantly enhanced wound healing in normal and diabetic mice compared with that of… 

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Mesenchymal stromal cells pretreated with pro‐inflammatory cytokines promote skin wound healing through VEGFC‐mediated angiogenesis

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Bone marrow‐derived mesenchymal stromal cells accelerate wound healing in the rat

  • K. McFarlinXiaohua Gao S. Gautam
  • Medicine
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2006
Cell therapy with BMSCs has the potential to augment healing of surgical and cutaneous wounds and was associated with increased production of collagen in the wound and more rapid histologic maturation of wounds compared with untreated wounds.

Contribution of Bone Marrow–Derived Cells to Skin: Collagen Deposition and Wound Repair

It is found that normal skin is a target organ for bone marrow–derived cells from both the hematopoietic and the mesenchymal stem cell pool, and wound healing involves local cutaneous cells for reconstituting the epidermis but distant bone marrow-derived cells and the adjacent uninjured dermal mesenchymeal cells for reconstructing the dermal fibroblast population.

Leprdb Diabetic Mouse Bone Marrow Cells Inhibit Skin Wound Vascularization but Promote Wound Healing

Adult stem cell function may be impaired by type 2 diabetes; the ability to promote vascularization and wound healing are distinct functions of bone marrow cells; and neovascularization and wounds healing may not be tightly coupled.

Allogeneic fibroblasts in dermal substitutes induce inflammation and scar formation

For optimal restoration of dermal skin function with minimal scar formation, skin substitutes containing autologous fibro Blasts are preferred over skin substitutes with allogeneic fibroblasts.

Local Delivery of Marrow-Derived Stromal Cells Augments Collateral Perfusion Through Paracrine Mechanisms

MSC injection improved limb function and appearance, reduced the incidence of auto-amputation, and attenuated muscle atrophy and fibrosis, suggesting MSCs can contribute to collateral remodeling through paracrine mechanisms.

Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction.

The results of a randomized study of bone-marrow-derived mesenchymal stem cells, administered to pigs, which offer several new insights regarding cellular cardiomyoplasty demonstrate that the direct injection of cellular grafts into damaged myocardium is safe and effective in the perii-nfarct period.

Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells

This is the first report to show that MSCs injected at 7 days after stroke improve long-term neurological outcome in older animals, and reactive astrocytes responding to MSC treatment of ischemia may also promote axonal regeneration during long‐term recovery.