Mesenchymal Stem Cells

  title={Mesenchymal Stem Cells},
  author={Arnold I. Caplan},
  pages={6 - 9}
  • A. Caplan
  • Published 1 September 1991
  • Biology
  • Cartilage
Bone and cartilage formation in the embryo and repair and turnover in the adult involve the progeny of a small number of cells called mesenchymal stem cells. These cells divide, and their progeny become committed to a specific and distinctive phenotypic pathway, a lineage with discrete steps and, finally, end‐stage cells involved with fabrication of a unique tissue type, e.g., cartilage or bone. Local cuing (extrinsic factors) and the genomic potential (intrinsic factors) interact at each… 

Mesenchymal stem cells: Sources, phenotype, and differentiation potential

A model of parent-progeny relationships of stromal cells is proposed, and the problems of regulation of proliferation and differentiation of mesenchymal precursors as well as their role in the maintenance of regeneration and tissue functioning are discussed.

28 – Mesenchymal Stem Cells

Cartilage engineering from mesenchymal stem cells.

Growth factors most commonly used for in vitro cultivation of cartilage tissue belong to the fibroblast growth factor (FGF) family, the transforming growth factor-beta (TGF-β) super-family, and the insulin-like growth factors (IGF) family.

Mesenchymal Stem Cells

The in vitro and in vivo study of bone marrow-derived mesenchymal stem cells (MSCs) is important in developing a comprehensive understanding of the dynamic processes that occur in regenerating tissues and the roles that MSCs play.

Mesenchymal Stem Cells in Tissue Engineering

An underappreciated source of knowledge lies in the relationship between fetal development and adult tissue repair, and a more thorough understanding of the events of development as they pertain to cartilage organogenesis may help elucidate some of the unknowns of adult tissue Repair.

"Mesenchymal" stem cells.

  • P. Bianco
  • Biology
    Annual review of cell and developmental biology
  • 2014
How the two opposing descriptions of so-called mesenchymal stem cells developed, conceptually and experimentally, are discussed, and the confusion arising from their collision is clarified are discussed.

The concept of mesenchymal stem cells.

MSCs appear to constitute a heterogeneous population of undifferentiated and committed, lineage-primed cells, capable of homing upon engraftment to a number of growth microenvironments, extensive proliferation, producing large numbers of differentiated progeny, and functional tissue repair after injury.

Stem cells for regenerative medicine: advances in the engineering of tissues and organs

The state of the art in tissue engineering with mesenchymal stem and mesenchYCal progenitor cells with emphasis on bone and cartilage reconstruction is reviewed and several issues of importance, especially with regard to the clinical application of mesenchyal stem cells, are discussed.