Mesenchymal Stem Cells; Defining the Future of Regenerative Medicine

@inproceedings{HeiraniTabasi2015MesenchymalSC,
  title={Mesenchymal Stem Cells; Defining the Future of Regenerative Medicine},
  author={Asieh Heirani-Tabasi and M Hassanzadeh and Shabnam Hemmati-Sadeghi and Mina Shahriyari and Mahmood Raeesolmohaddeseen},
  year={2015}
}
Cell therapy has been considered as the third pillar of medicine. There are several kinds of cells attracted researchers attention whereas the growing interest in mesenchymal stem cells (MSCs) for regenerative purposes has enabled them to explore the versatile characteristics for regenerative purposes. So far, near about 5000 clinical trials using MSCs, authenticating the clinical applicability of these cells. Their multipotent differentiation and unique immunosuppressive properties have made… Expand

Tables from this paper

Hypoxia-based Stem/Progenitor Cell Therapy: Focus on CXCR4/SDF-1 Axis
TLDR
P pivotal roles of HIF-1α /CXCR4/SDF-1 pathway in homing of progenitor/Stem cell which were affected by physical hypoxia as well as various hypoxiamimicking agents are reviewed. Expand
Critical Issues in Successful Production of Skin Substitutes for Wound Healing
Novel findings on fabrication techniques for bioactive materials, discovering further basic knowledge about wound healing process, and availability of stem cells as alternative candidate forExpand
Critical Issues in Successful Production of Skin Substitutes for Wound Healing
TLDR
The progress that has been made to date in the field of skin substitutes and the critical issues that are still hindering successful production and bench to bedside translation of BSS are described and restricting the availability of these innovative therapeutic constructs. Expand
Chemokine Receptors Expression in MSCs: Comparative Analysis in Different Sources and Passages
TLDR
To improve homing of MSCs by means of chemokine/their receptors axis, the source of isolation and passage number should be considered for clinical applications. Expand
Migration Gene Expression of Human Umbilical Cord Mesenchymal Stem Cells: A Comparison between Monophosphoryl Lipid A and Supernatant of Lactobacillus acidophilus.
TLDR
It can be suggested that MPLA has more prominent results than SLA, but both treatments can probably be considered as an inducing factor in migration. Expand
Bone marrow mesenchymal stem cell-derived exosomes protect against myocardial infarction by promoting autophagy
TLDR
Rat MSC exosomes were revealed to suppress myocardial injury and the myocardiocyte functions that were induced by I/R, and decreased apoptotic protease activating factor-1 and increased autophagy-related protein 13 expression. Expand
Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells
  • Jun-Hwee Jang, Eun-Jung Lee
  • Medicine
  • Materials
  • 2021
MXenes with a two-dimensional (2D) structure have attracted attention as potential biomedical materials. In this study, Ti3C2 MXene particles with 2D-lamellar structures were intercalated and theirExpand

References

SHOWING 1-10 OF 66 REFERENCES
Mesenchymal stem cells: a new trend for cell therapy
TLDR
Recent opinions on methods, timing and cell sources for MSC administration in clinical applications are summarized, and an overview of mechanisms that are significant in MSC-mediated therapies are provided. Expand
Mesenchymal Stem Cell Therapy: Clinical Progress and Opportunities for Advancement
TLDR
A polarization paradigm where different priming stimuli, reflective of an injured tissue, induce either a pro-inflammatory or immunosuppressive MSC phenotype, provides the potential for manipulating MSCs to obtain more predictable clinical effects. Expand
Mesenchymal stem cells as therapeutics.
TLDR
Representing MSCs as drug-loaded particles may allow for pharmacokinetic models to predict the therapeutic activity of MSC transplants as a function of drug delivery mode and is armed to usher in the next generation of stem cell therapeutics. Expand
Clinical applications of mesenchymal stem cells
TLDR
An overview of the recent clinical findings related to MSC therapeutic effects is provided, including roles of MSCs in clinical trials conducted to treat graft-versus-host-disease (GVHD) and cardiovascular diseases are highlighted. Expand
Mesenchymal stem cell based therapy for osteo‐diseases
TLDR
It is reported that MSC therapy for osteo‐diseases needs optimization in its standards to achieve acceptable results so that it can apply in daily routine clinical practice. Expand
Mesenchymal Stem Cells for Regenerative Therapy: Optimization of Cell Preparation Protocols
TLDR
This review article summarizes protocols to isolate and expand bone marrow-derived MSCs in 47 recent clinical trials of MSC-based therapy, which were published after 2007 onwards and provided sufficient methodological information. Expand
Mesenchymal stem cells: paradoxes of passaging.
TLDR
The aim of this review is to critically analyze the field of MSC biology, particularly with respect to the current paradox between in vitro promise and in vivo efficacy. Expand
Bone marrow mesenchymal stem cells
TLDR
Both a systematic phenotypic in vivo characterization of the MSC population and the development of a reproducible and faithful in vivo assay that would test the ability of MSCs to self‐renew, proliferate, and differentiate in vivo are just beginning. Expand
Searching for Alternative Sources of Postnatal Human Mesenchymal Stem Cells: Candidate MSC‐Like Cells from Umbilical Cord
TLDR
An attempt to isolate MSCs from the subendothelial layer of umbilical cord vein using two standard methodological approaches and results suggest that cord vasculature contains a high number of MSC‐like elements forming colonies of fibroblastoid cells that may be successfully expanded in culture. Expand
Adult mesenchymal stem cells: potential for muscle and tendon regeneration and use in gene therapy.
TLDR
Recent developments related to adult stem cell research and in particular, in the arena of mesenchymal stem cell (MSC) research are described, demonstrating that transduced MSCs injected into skeletal muscle can persist and express secreted gene products. Expand
...
1
2
3
4
5
...