Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice.

@article{SegalGavish2016MesenchymalSC,
  title={Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice.},
  author={Hadar Segal-Gavish and Golan Karvat and Noy Barak and Ran Barzilay and Javier Ganz and Liat Edry and Israel Aharony and Daniel Offen and Tali Kimchi},
  journal={Autism research : official journal of the International Society for Autism Research},
  year={2016},
  volume={9 1},
  pages={17-32}
}
Autism spectrum disorders (ASD) are characterized by social communication deficits, cognitive rigidity, and repetitive stereotyped behaviors. Mesenchymal stem cells (MSC) have a paracrine regenerative effect, and were speculated to be a potential therapy for ASD. The BTBR inbred mouse strain is a commonly used model of ASD as it demonstrates robust behavioral deficits consistent with the diagnostic criteria for ASD. BTBR mice also exhibit decreased brain-derived neurotrophic factor (BDNF… CONTINUE READING
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