Mesenchymal Stem Cell Therapy Stimulates Endogenous Host Progenitor Cells to Improve Colonic Epithelial Regeneration

@inproceedings{Smont2013MesenchymalSC,
  title={Mesenchymal Stem Cell Therapy Stimulates Endogenous Host Progenitor Cells to Improve Colonic Epithelial Regeneration},
  author={Alexandra S{\'e}mont and Christelle Demarquay and Rapha{\"e}lle Bessout and Christelle M Durand and Marc Benderitter and No{\"e}lle Mathieu},
  booktitle={PloS one},
  year={2013}
}
Patients who undergo pelvic radiotherapy may develop severe and chronic complications resulting from gastrointestinal alterations. The lack of curative treatment highlights the importance of novel and effective therapeutic strategies. We thus tested the therapeutic benefit of mesenchymal stem cells (MSC) treatment and proposed molecular mechanisms of action. MSC efficacy was tested in an experimental model of radiation-induced severe colonic ulceration histologically similar to that observed in… CONTINUE READING