Mesenchymal Stem Cell-Mediated Mitochondrial Transfer: a Therapeutic Approach for Ischemic Stroke.

  title={Mesenchymal Stem Cell-Mediated Mitochondrial Transfer: a Therapeutic Approach for Ischemic Stroke.},
  author={Meng Lu and Jin-Dong Guo and Bowen Wu and Yuhui Zhou and Mi-Shan Wu and Maryam Farzaneh and Seyed Esmaeil Khoshnam},
  journal={Translational stroke research},
Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction is one of the hallmarks of stroke-induced neuronal death, and maintaining mitochondrial function is essential in cell survival and neurological progress following ischemic stroke. Stem cell-mediated mitochondrial transfer represents an emerging therapeutic approach for ischemic stroke. Accumulating evidence suggests that mesenchymal stem cells (MSCs) can directly transfer healthy mitochondria to… 
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May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells
  • C. Borlongan, Hung Nguyen, E. Napoli
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2019
The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.
Mitochondrial targeting as a novel therapy for stroke
This review focuses on the current evidence of mitochondrial dysfunction in stroke, investigating favorable approaches of healthy mitochondria transfer in ischemic neurons, and exploring the potential of mitochondria-based cellular therapy for clinical applications.
Mesenchymal stem cell-based therapy for ischemic stroke
The present review summarizes the current literature on the use of mesenchymal stem cells to treat ischemic stroke and indicates that further studies investigating the mechanisms underlying mesenchyal stem cell tissue healing effects are warranted and would be of benefit to the field.
Mitochondria in Ischemic Stroke: New Insight and Implications
The potential of mitochondria as therapeutic targets for stroke treatment and recent findings on mitochondrial transfer in acute stroke are highlighted and valuable insights for clinical strategies are provided.
Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke
This review will focus on MSCs, stem cells widely utilized in current medical research, and evaluate their effect and potential of improving outcomes in ischemic stroke.
Stem Cell-Based Therapies for Ischemic Stroke
Although several clinical studies have shown the high efficiency and safety of stem cell in stroke management, mainly MSCs, some issues regarding to cell homing, survival, tracking, safety, and optimal cell transplantation protocol, such as cell dose and time window, should be addressed.
Mesenchymal stem cells and their mitochondrial transfer: a double-edged sword
An overview of the biology, function, niches and signaling that play a role in tissue repair and the pathologies of cancer growth and metastasis linked to mitochondrial exchange between cancer cells and surrounding stromal cells is highlighted.