Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine

  title={Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine},
  author={Wataru Sonoyama and Yi Liu and Dianji Fang and Takayoshi Yamaza and B Seo and Chunmei Zhang and He Liu and Stan Gronthos and Cun-yu Wang and Songtao Shi and Songlin Wang},
  journal={PLoS ONE},
  pages={469 - 479}
Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work… CONTINUE READING
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