Mesenchymal Stem Cell Conditioned Medium Promotes Proliferation and Migration of Alveolar Epithelial Cells under Septic Conditions In Vitro via the JNK-P38 Signaling Pathway.

@article{Chen2015MesenchymalSC,
  title={Mesenchymal Stem Cell Conditioned Medium Promotes Proliferation and Migration of Alveolar Epithelial Cells under Septic Conditions In Vitro via the JNK-P38 Signaling Pathway.},
  author={Jie Chen and Yanqin Li and Haojie Hao and Chonghui Li and Yu Du and Ye Qing Hu and Jian Li and Zhixin Liang and Chunsun Li and Jiejie Liu and Liangan Chen},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2015},
  volume={37 5},
  pages={
          1830-46
        }
}
BACKGROUND/AIMS Mesenchymal stem cell (MSC) based therapies may be useful for treating acute respiratory distress syndrome (ARDS), but the underlying mechanisms are incompletely understood. We investigated the impact of human umbilical cord Wharton's jelly-derived MSC (hUC-MSC) secreted factors on alveolar epithelial cells under septic conditions and determined the relevant intracellular signaling pathways. METHODS Human alveolar epithelial cells (AEC) and primary human small airway… CONTINUE READING

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