Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.

@article{Young1986MesencephalicDN,
  title={Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.},
  author={W Scott Young and Tom I. Bonner and Mark R. Brann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 24},
  pages={9827-31}
}
We used in situ hybridization histochemistry with synthetic oligodeoxyribonucleotide probes to identify cells that synthesize mRNAs encoding tyrosine hydroxylase in the mesencephalon and substance P, enkephalin, and dynorphin in the rat forebrain. Dopaminergic cells in the mesencephalon project to the forebrain and influence neuropeptide levels. We examined the effect of unilateral 6-hydroxydopamine lesions (which eliminated tyrosine hydroxylase mRNA-containing cells in the mesencephalon) on… CONTINUE READING
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