Mesencephalic Trigeminal Nucleus Development Is Dependent on Krox-20 Expression

  title={Mesencephalic Trigeminal Nucleus Development Is Dependent on Krox-20 Expression},
  author={Shampa De and A. Nguyen and C. Shuler and Jack E. Turman},
  journal={Developmental Neuroscience},
  pages={49 - 58}
  • Shampa De, A. Nguyen, +1 author Jack E. Turman Jr.
  • Published 2005
  • Biology, Medicine
  • Developmental Neuroscience
  • Krox-20, a C2H2-type zinc-finger transcription factor, plays an important role in rhombomere development. This study reveals that the Krox-20 null mutation impacts the development of mesencephalic trigeminal (Me5) neurons, a cell group traditionally thought to emerge from the mesencephalon. Based on cell counting studies, we show that Krox-20 null mutants have twice as many Me5 neurons relative to wildtypes at E15, but by birth have half the number of Me5 cells as wildtypes. TUNEL studies… CONTINUE READING
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    • 7
    Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11
    • 15
    • PDF
    Emergence of the sensory nervous system as defined by Foxs1 expression.
    • 49
    The development of mastication in rodents: from neurons to behaviors.
    • J. Turman
    • Biology, Medicine
    • Archives of oral biology
    • 2007
    • 18
    Generation of the masticatory central pattern and its modulation by sensory feedback
    • 72


    The ontogeny of Krox-20 expression in brainstem and cerebellar neurons
    • 10
    Morphogenesis of the trigeminal mesencephalic nucleus in the hamster: cytogenesis and neurone death.
    • K. Alley
    • Biology, Medicine
    • Journal of embryology and experimental morphology
    • 1974
    • 56
    • Highly Influential
    • PDF
    Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors
    • 230
    Hindbrain patterning: Krox20 couples segmentation and specification of regional identity.
    • 96
    • PDF
    Progressive spatial restriction of Sek-1 and Krox-20 gene expression during hindbrain segmentation.
    • 125
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