Mesencephalic Trigeminal Nucleus Development Is Dependent on Krox-20 Expression

@article{De2005MesencephalicTN,
  title={Mesencephalic Trigeminal Nucleus Development Is Dependent on Krox-20 Expression},
  author={Shampa De and A. Nguyen and C. Shuler and Jack E. Turman},
  journal={Developmental Neuroscience},
  year={2005},
  volume={27},
  pages={49 - 58}
}
  • Shampa De, A. Nguyen, +1 author Jack E. Turman Jr.
  • Published 2005
  • Biology, Medicine
  • Developmental Neuroscience
  • Krox-20, a C2H2-type zinc-finger transcription factor, plays an important role in rhombomere development. This study reveals that the Krox-20 null mutation impacts the development of mesencephalic trigeminal (Me5) neurons, a cell group traditionally thought to emerge from the mesencephalon. Based on cell counting studies, we show that Krox-20 null mutants have twice as many Me5 neurons relative to wildtypes at E15, but by birth have half the number of Me5 cells as wildtypes. TUNEL studies… CONTINUE READING
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