Mesangiocapillary glomerulonephritis in Down's syndrome.

  title={Mesangiocapillary glomerulonephritis in Down's syndrome.},
  author={Subhash Kumari Gupta and V S Venkataseshan and Jacob Churg},
  journal={American journal of nephrology},
  volume={11 2},
The clinical and pathologic features of progressive renal disease in 4 patients with Down's syndrome are described. All patients were male, between 20 and 30 years of age at the time of clinical presentation. Three out of 4 had proteinuria, and 2 had hematuria. Serologic tests for hepatitis B virus infection and antinuclear antibodies performed in 2 patients were negative. Examination of renal tissue from biopsy and/or from autopsy revealed mesangiocapillary glomerulonephritis (MCGN), type 1… CONTINUE READING


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