Mesangial proliferative nephritis in man is associated with increased expression of the cell survival factor, Bcl-2.

@article{Uda1998MesangialPN,
  title={Mesangial proliferative nephritis in man is associated with increased expression of the cell survival factor, Bcl-2.},
  author={Susumu Uda and Ashio Yoshimura and Youichi Sugenoya and Kiyoko Inui and Takayasu Taira and Terukuni Ideura},
  journal={American journal of nephrology},
  year={1998},
  volume={18 4},
  pages={291-5}
}
Although most studies suggest that the hypercellularity in mesangial proliferative nephritis is due to increased cell proliferation, we hypothesized that it may also be due to increased expression of survival factors that may block their removal (apoptosis). We therefore studied the expression of apoptosis preventing/delaying the bcl-2 gene product in the… CONTINUE READING