Mesangial cell protein kinase C isozyme activation in the diabetic milieu.

  title={Mesangial cell protein kinase C isozyme activation in the diabetic milieu.},
  author={Catharine I. Whiteside and John A Dlugosz},
  journal={American journal of physiology. Renal physiology},
  volume={282 6},
High-glucose-induced activation of mesangial cell protein kinase C (PKC) contributes significantly to the pathogenesis of diabetic nephropathy. Excess glucose metabolism through the polyol pathway leads to de novo synthesis of both diacylglyerol (DAG) and phosphatidic acid, which may account for increased mesangial cell PKC-alpha, -beta, -delta, -epsilon, and -zeta activation/translocation observed within 48-h exposure to high glucose. Raised intracellular glucose causes generation of reactive… CONTINUE READING


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