Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.

@article{Mahimainathan2006MesangialCH,
  title={Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.},
  author={Lenin Mahimainathan and Falguni Das and Balachandar A Venkatesan and Goutam Ghosh Choudhury},
  journal={Diabetes},
  year={2006},
  volume={55 7},
  pages={2115-25}
}
Diabetic nephropathy is characterized early in its course by glomerular hypertrophy and, importantly, mesangial hypertrophy, which correlate with eventual glomerulosclerosis. The mechanism of hypertrophy, however, is not known. Gene disruption of the tumor suppressor PTEN, a negative regulator of the phosphatidylinositol 3-kinase/Akt pathway, in fruit flies and mice demonstrated its role in size control in a cell-specific manner. Here, we investigated the mechanism of mesangial hypertrophy in… CONTINUE READING
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Inactivation of platelet-derived growth MESANGIAL HYPERTROPHY AND PTEN 2124 DIABETES

  • L Mahimainathan, GG Choudhury
  • VOL. 55,
  • 2006
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