Mesangial cell filamentous actin disassembly and hypocontractility in high glucose are mediated by PKC-zeta.

@article{Dlugosz2002MesangialCF,
  title={Mesangial cell filamentous actin disassembly and hypocontractility in high glucose are mediated by PKC-zeta.},
  author={John Antoni Dlugosz and Snezana Munk and Eric Ispanovic and Howard J. Goldberg and Catharine I. Whiteside},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={282 1},
  pages={
          F151-63
        }
}
In high glucose (HG), mesangial cells (MCs) lose their contractile response to endothelin-1 (ET-1) coincidently with filamentous (F)-actin disassembly. We postulated that these MC phenotypic changes are mediated by altered protein kinase C (PKC) isozyme activity, myosin light chain (MLC(20)) phosphorylation, or Ca(2+) signaling. MCs were growth arrested for 24 h in 0.5% fetal bovine serum (FBS)-DMEM in 5.6 (normal glucose; NG) or 30 mM glucose (high glucose; HG). In HG, the planar area was… CONTINUE READING

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