Mesalamine and azathioprine modulate junctional complexes and restore epithelial barrier function in intestinal inflammation

@inproceedings{Khare2019MesalamineAA,
  title={Mesalamine and azathioprine modulate junctional complexes and restore epithelial barrier function in intestinal inflammation},
  author={Vineeta Khare and Anita Krnjic and Adrian P. Frick and Christina Gmainer and Mario Asboth and Kristine Michelle Jimenez and Michaela Lang and Maximilian Baumgartner and Rayko Evstatiev and Christoph Gasch{\'e}},
  booktitle={Scientific Reports},
  year={2019}
}
Disruption of mucosal structure and barrier function contribute to the pathogenesis of inflammatory bowel disease (IBD). Efficacy of therapy in IBD is based on endoscopic mucosal healing, which occurs by a dynamic interplay of epithelial cell regeneration, migration and differentiation. Both mesalamine (5-ASA) and azathioprine (AZTP) promote this process through mechanisms not clearly understood. We examined molecular pathways implicated in epithelial barrier function that were altered by 5-ASA… CONTINUE READING
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