Merotelic kinetochore orientation, aneuploidy, and cancer.

Abstract

Accurate chromosome segregation in mitosis is crucial to maintain a diploid chromosome number. A majority of cancer cells are aneuploid and chromosomally unstable, i.e. they tend to gain and lose chromosomes at each mitotic division. Chromosome mis-segregation can arise when cells progress through mitosis with mis-attached kinetochores. Merotelic… (More)
DOI: 10.1016/j.bbcan.2008.05.003

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