Meropenem-clavulanic acid has high in vitro activity against multidrug-resistant Mycobacterium tuberculosis.

@article{Forsman2015MeropenemclavulanicAH,
  title={Meropenem-clavulanic acid has high in vitro activity against multidrug-resistant Mycobacterium tuberculosis.},
  author={L Davies Forsman and Christian G. Giske and Judith Bruchfeld and T Sch{\"o}n and Pontus Jur{\'e}en and Kristian {\"A}ngeby},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 6},
  pages={3630-2}
}
We investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68 Mycobacterium tuberculosis isolates. We included predominantly multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) isolates, since the activity of MEM-CLA for resistant isolates has previously not been studied extensively. Using Middlebrook 7H10 medium, all but four isolates showed an MIC distribution of 0.125 to 2 mg/liter for MEM-CLA, below the non-species-related breakpoint for MEM of 2 mg/liter… CONTINUE READING