Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infections.

@article{Capitano2004MeropenemAA,
  title={Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infections.},
  author={Blair Capitano and David P Nicolau and Brian A. Potoski and Karin E Byers and Michael H Horowitz and Raman Venkataramanan and David L Paterson},
  journal={Pharmacotherapy},
  year={2004},
  volume={24 6},
  pages={803-7}
}
The treatment of gram-negative infection of the central nervous system (CNS) presents a clinical challenge due to antibiotic resistance and difficulties with penetration into the cerebrospinal fluid (CSF). Two patients with gram-negative CNS infections were treated successfully with high-dose, prolonged infusions of meropenem. The CSF meropenem concentrations exceeded the minimum inhibitory concentration of the pathogen for virtually the entire dosing interval in both cases. Our experience… CONTINUE READING