Merlin differentially associates with the microtubule and actin cytoskeleton.

  title={Merlin differentially associates with the microtubule and actin cytoskeleton.},
  author={Hua-mei Xu and David H Gutmann},
  journal={Journal of neuroscience research},
  volume={51 3},
The neurofibromatosis 2 (NF2) suppressor gene encodes a protein termed merlin (or schwannomin) with sequence similarity to a family of proteins that link the actin cytoskeleton to cell surface glycoproteins. Members of this ERM family of proteins include ezrin, radixin, and moesin. These proteins contain a carboxyl (C-) terminus actin binding site. In contrast to the ERM proteins, merlin lacks the conventional C-terminal actin binding site, but still localizes to the ruffling edge of plasma… CONTINUE READING
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