Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis

@article{SastreGarau2009MerkelCC,
  title={Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis},
  author={Xavier Sastre-Garau and Martine Peter and M‐F. Avril and H{\'e}l{\`e}ne Laude and J{\'e}r{\^o}me Couturier and Flore Rozenberg and Anna Almeida and Françoise Boitier and Agn{\`e}s Carlotti and Beno{\^i}t Couturaud and Nicolas Dupin},
  journal={The Journal of Pathology},
  year={2009},
  volume={218}
}
Merkel cell carcinoma (MCC), a skin tumour with neuroendocrine features, was recently found to be associated with a new type of human polyomavirus, called Merkel cell virus (MCV). We investigated the specificity of this association as well as a causal role of MCV in oncogenesis. DNA and RNA from ten cases of MCC were analysed using PCR and RT‐PCR. DNA from 1241 specimens of a wide range of human tumours was also analysed. The DIPS technique was used to identify the integration locus of viral… Expand
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TLDR
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TO THE EDITOR Merkel cell carcinoma (MCC) is an increasingly common neuroendocrine cancer of the skin. MCC is an aggressive malignancy that is a significant cause of non-melanoma skin cancerExpand
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