Merkel cell carcinoma and HIV infection

@article{Engels2002MerkelCC,
  title={Merkel cell carcinoma and HIV infection},
  author={Eric A. Engels and Morten Frisch and James J. Goedert and Robert J. Biggar and Robert W. Miller},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={497-498}
}
Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity. To assess further whether immune suppression increases MCC risk, we studied its occurrence in a cohort of 309365 individuals with acquired immunodeficiency syndrome (AIDS) by using linked AIDS and cancer registries. We identified six cases of MCC, corresponding to a relative risk of 13.4 (95% CI 4.9-29.1) compared with… Expand
Merkel Cell Polyomavirus and Merkel Cell Carcinoma, France
TLDR
The similarity between MCC and Kaposi sarcoma may support the hypothesis of an infectious origin of MCC, a malignant tumor associated with human herpesvirus 8 infection. Expand
Merkel Cell Carcinoma in the HIV-1/AIDS Patient.
TLDR
MCC in patients living with HIV-1/AIDS are treated with similar modalities as HIV- 1 uninfected individuals with MCC, and checkpoint blockade inhibitors targeting PD-1 and PD-L1 have shown remarkable activity including durable long-term. Expand
New virus associated with merkel cell carcinoma development.
TLDR
Investigation discovered a genome encompassing 5387 base pairs of a new polyomvirus, subsequently named the Merkel cell polyomavirus, suggesting UV radiation exposure may play a role in the development of MCC. Expand
Merkel Cell Carcinoma in Immunosuppressed Patients
TLDR
Overall, immunocompromised patients also appear to have an early onset and more aggressive course of MCC, with poorer outcomes, and recommendations for multidisciplinary approaches are proposed to effectively prevent and manage MCC in these patients. Expand
Merkel Cell Carcinoma: An Update and Immunotherapy
TLDR
Several studies have shown that a subset of MCCs express PD-1 on tumor-infiltrating lymphocytes and express PD, which suggests an endogenous tumor-reactive immune response that might be unleashed by anti-PD-1 or anti- PD-L1 drugs. Expand
Merkel cell carcinoma.
TLDR
The increasing incidence, the aggressive behavior of this malignancy, the unknown etio-pathogenesis, and the paucity of options for the treatment of advanced disease call for the need of optimal, standardized management of this neoplasm. Expand
Updates on Merkel Cell Carcinoma.
TLDR
Surgical excision with margins of 1 to 2 cm remains first-line therapy for early-stage MCC, but robust evidence supporting immunotherapy for patients with advanced disease has led to recent approval of immune checkpoint inhibitors in the treatment of advanced MCC. Expand
Merkel cell carcinoma in organ transplant recipients: Case reports and review of the literature
TLDR
2 cases of MCC occurring in organ transplant recipients (OTRs) are reported, illustrating how iatrogenic immunosuppression in the setting of organ transplantation can impact tumor progression and potentially decrease survival. Expand
Merkel Cell Carcinoma: Review
TLDR
Merkel cell carcinoma is synonymous with primary cutaneous neuroendocrine carcinoma, but there is also an increased incidence among immunosuppressed patients, and Sentinel lymph node biopsy has become an integral part of the staging of patients with MCC. Expand
Merkel Cell Carcinoma and Human Immunodeficiency Virus: More Than a Non-Acquired Immunodeficiency Syndrome-Defining Tumor?
TLDR
The association of MCC with HIV is reviewed and the relationship of moderate but prolonged immunosuppression, which results from HIV disease, and its connection with non-acquired immunodeficiency syndrome-defining cancers is discussed, suggesting that MCC and other malignancies may need to be reconsidered for classification as acquired immuno-suffering conditions. Expand
...
1
2
3
4
5
...

References

SHOWING 1-7 OF 7 REFERENCES
Merkel cell carcinoma and melanoma: etiological similarities and differences.
  • R. W. Miller, C. Rabkin
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1999
TLDR
MCC and melanoma are similarly related to sun exposure and immunosuppression, but they differ markedly from one another in their distributions by age, race, and anatomical site, especially the face. Expand
Merkel's cell carcinoma in organ recipients: report of 41 cases.
TLDR
In transplant patients, MCC probably proved to be more aggressive than in the general population in that 68% of patients developed lymph node metastases and 56% died of their malignancies. Expand
Association of cancer with AIDS-related immunosuppression in adults.
TLDR
Although occurring in overall excess, most non-AIDS-defining cancers do not appear to be influenced by the advancing immunosuppression associated with HIV disease progression. Expand
Merkel cell carcinoma of the skin: imaging and clinical features in 93 cases.
TLDR
Imaging studies have a limited role in diagnosis of the clinically evident primary skin lesions, but may be helpful in the assessment of the depth of the invasion and are crucial in the evaluation of regional and distant metastatic disease. Expand
Physiology and pathophysiology of the aquaporin‐2 water channel
TLDR
Because of its importance for normal water homeostasis and its involvement in many water balance disorders, aquaporin-2, the predominant vasopressin-regulated water channel of the renal collecting duct, is discussed in detail. Expand
Effects of vasopressin on human memory functions.
TLDR
Cognitively unimpaired, as well as cognitively impaired adults, treated with DDAVP for a period of several days, learn information more effectively, as measured by the completeness, organization, and consistency of recall. Expand
Abnormal diurnal rhythm of plasma vasopressin and urinary output in patients with enuresis.
TLDR
An abnormal diurnal rhythm of AVP seems to be an important pathophysiological factor in enuresis, explaining the abnormally high nocturnal urinary volume and the low noctual urinary osmolality found in these patients. Expand