Merkel Cell Carcinoma in the HIV-1/AIDS Patient.
- MedicineCancer treatment and research
MCC in patients living with HIV-1/AIDS are treated with similar modalities as HIV- 1 uninfected individuals with MCC, and checkpoint blockade inhibitors targeting PD-1 and PD-L1 have shown remarkable activity including durable long-term.
New virus associated with merkel cell carcinoma development.
- Medicine, BiologyJournal of the National Comprehensive Cancer Network : JNCCN
Investigation discovered a genome encompassing 5387 base pairs of a new polyomvirus, subsequently named the Merkel cell polyomavirus, suggesting UV radiation exposure may play a role in the development of MCC.
Merkel Cell Carcinoma in Immunosuppressed Patients
- Medicine, BiologyCancers
Overall, immunocompromised patients also appear to have an early onset and more aggressive course of MCC, with poorer outcomes, and recommendations for multidisciplinary approaches are proposed to effectively prevent and manage MCC in these patients.
Merkel Cell Carcinoma: An Update and Immunotherapy
- Medicine, BiologyFront. Oncol.
Several studies have shown that a subset of MCCs express PD-1 on tumor-infiltrating lymphocytes and express PD, which suggests an endogenous tumor-reactive immune response that might be unleashed by anti-PD-1 or anti- PD-L1 drugs.
Merkel cell carcinoma.
- MedicineCancer treatment and research
The increasing incidence, the aggressive behavior of this malignancy, the unknown etio-pathogenesis, and the paucity of options for the treatment of advanced disease call for the need of optimal, standardized management of this neoplasm.
Merkel Cell Carcinoma: Review
- MedicineAdvances in anatomic pathology
Merkel cell carcinoma is synonymous with primary cutaneous neuroendocrine carcinoma, but there is also an increased incidence among immunosuppressed patients, and Sentinel lymph node biopsy has become an integral part of the staging of patients with MCC.
Merkel cell carcinoma in organ transplant recipients: Case reports and review of the literature
- MedicineJAAD case reports
Merkel Cell Carcinoma and Human Immunodeficiency Virus: More Than a Non-Acquired Immunodeficiency Syndrome-Defining Tumor?
- Medicine, Biology
The association of MCC with HIV is reviewed and the relationship of moderate but prolonged immunosuppression, which results from HIV disease, and its connection with non-acquired immunodeficiency syndrome-defining cancers is discussed, suggesting that MCC and other malignancies may need to be reconsidered for classification as acquired immuno-suffering conditions.
SHOWING 1-7 OF 7 REFERENCES
Merkel cell carcinoma and melanoma: etiological similarities and differences.
- MedicineCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
MCC and melanoma are similarly related to sun exposure and immunosuppression, but they differ markedly from one another in their distributions by age, race, and anatomical site, especially the face.
Merkel's cell carcinoma in organ recipients: report of 41 cases.
In transplant patients, MCC probably proved to be more aggressive than in the general population in that 68% of patients developed lymph node metastases and 56% died of their malignancies.
Association of cancer with AIDS-related immunosuppression in adults.
- Medicine, BiologyJAMA
Although occurring in overall excess, most non-AIDS-defining cancers do not appear to be influenced by the advancing immunosuppression associated with HIV disease progression.
Merkel cell carcinoma of the skin: imaging and clinical features in 93 cases.
- MedicineThe British journal of radiology
Imaging studies have a limited role in diagnosis of the clinically evident primary skin lesions, but may be helpful in the assessment of the depth of the invasion and are crucial in the evaluation of regional and distant metastatic disease.
Effects of vasopressin on human memory functions.
- Biology, PsychologyScience
Cognitively unimpaired, as well as cognitively impaired adults, treated with DDAVP for a period of several days, learn information more effectively, as measured by the completeness, organization, and consistency of recall.
Abnormal diurnal rhythm of plasma vasopressin and urinary output in patients with enuresis.
- Medicine, BiologyThe American journal of physiology
An abnormal diurnal rhythm of AVP seems to be an important pathophysiological factor in enuresis, explaining the abnormally high nocturnal urinary volume and the low noctual urinary osmolality found in these patients.
Physiology and pathophysiology of the aquaporin‐2 water channel
- Biology, Environmental ScienceCurrent opinion in nephrology and hypertension
Because of its importance for normal water homeostasis and its involvement in many water balance disorders, aquaporin-2, the predominant vasopressin-regulated water channel of the renal collecting duct, is discussed in detail.