Merkel cell carcinoma: recent insights and new treatment options

@article{Schrama2012MerkelCC,
  title={Merkel cell carcinoma: recent insights and new treatment options},
  author={David Schrama and Selma Ugurel and J{\"u}rgen Christian Becker},
  journal={Current Opinion in Oncology},
  year={2012},
  volume={24},
  pages={141–149}
}
Purpose of review Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin demonstrating a high propensity of recurrence and metastasis. Its 5-year disease-specific survival rate is only about 60%. Although MCC is still regarded as a very rare tumor entity, its incidence is rapidly increasing. In this regard, the American Cancer Society estimated almost 1500 new cases in the United States in 2008. Recent findings The newly identified Merkel cell polyomavirus (MCV… 
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A case of MCC is reported to alert medical professionals of this potentially fatal tumor, as early diagnosis and treatment may improve morbidity and mortality rates.
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According to the literature, neither chemotherapy nor molecular-targeted agents or immunotherapeutic strategies have shown promising effects in the therapy of the metastatic disease of MCC so far.
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TLDR
It is not very likely that MCC develops from differentiated MCs, but skin stem cells, probably from the epidermal lineage, are more likely to be cells of origin in MCC.
[A probable etiological role of Merkel cell polyomavirus in the development of Merkel cell carcinoma].
TLDR
This review summarizes the current knowledge related to Merkel cell carcinoma and the first oncogenic human polyomvirus, the Merkel cell polyomavirus, to promote the clinical adaptation of the information.
Merkel Cell Carcinoma (Cutaneous Neuroendocrine Carcinoma)
TLDR
The discovery of Merkel cell polyomavirus associated with MCC development is providing hope for the development of newer treatment methods, especially in immunocompromised individuals.
Multiple Primary Merkel Cell Carcinomas Presenting as Pruritic, Painful Lower Leg Tumors
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This case represents an unusual presentation of primary MCC and demonstrates further evidence that radiation as monotherapy is an effective local treatment option for inoperable MCC.
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A case of MCC is reported in an elderly male diagnosed and treated with chemotherapy and radiation, with a review of the literature of this rare malignancy.
MERKEL CELL CARCINOMA VERSUS METASTATIC SMALL CELL PRIMARY BRONCHOGENIC CARCINOMA
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The initial workup study of the differential diagnosis patient is emphasized, including evaluating clinical lymph nodes, a clinical history of any respiratory abnormality, and chest radiogram, to emphasize the importance of a multidisciplinary approach to the approach to this difficult differential diagnosis.
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Merkel cell carcinoma – pathogenesis, clinical aspects and treatment
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TLDR
Recent findings of the pathogenesis of MCC are summarized, an overview of clinical aspects are presented and treatment options for MCCs are discussed.
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TLDR
This is the first report analysing CK20, CK19, CD117 and ST3 protein expression of tumour cells as a function of presence of MCPyV DNA in a large cohort of MCC.
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TLDR
Although MCV-positive andMCV-negative MCCs may have different etiologies, these tumors have comparable clinical behaviors and prognosis.
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TO THE EDITOR Merkel cell carcinoma (MCC) is an increasingly common neuroendocrine cancer of the skin. MCC is an aggressive malignancy that is a significant cause of non-melanoma skin cancer
The etiology and epidemiology of merkel cell carcinoma.
Early aggressive treatment for Merkel cell carcinoma improves outcome.
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TLDR
The different results achieved using cisplatin, docetaxel, and cetuximab led to the conclusion that an individual chemoresponse testing in a predictive short time assay might potentially be a useful diagnostic tool in identifying potentially effective chemotherapy treatments.
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TLDR
Recent studies have shown that Ras/MAP kinase activity is absent and possibly detrimental to this cancer, which makes MCC distinct from other UV--induced skin cancers and highlights the question of what drives this malignancy.
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