Merkel cell carcinoma: recent insights and new treatment options

  title={Merkel cell carcinoma: recent insights and new treatment options},
  author={David Schrama and Selma Ugurel and J{\"u}rgen Christian Becker},
  journal={Current Opinion in Oncology},
Purpose of review Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin demonstrating a high propensity of recurrence and metastasis. Its 5-year disease-specific survival rate is only about 60%. Although MCC is still regarded as a very rare tumor entity, its incidence is rapidly increasing. In this regard, the American Cancer Society estimated almost 1500 new cases in the United States in 2008. Recent findings The newly identified Merkel cell polyomavirus (MCV… 

Merkel Cell Carcinoma of the Digit.

A case of MCC is reported to alert medical professionals of this potentially fatal tumor, as early diagnosis and treatment may improve morbidity and mortality rates.

Which Are the Cells of Origin in Merkel Cell Carcinoma?

It is not very likely that MCC develops from differentiated MCs, but skin stem cells, probably from the epidermal lineage, are more likely to be cells of origin in MCC.

[A probable etiological role of Merkel cell polyomavirus in the development of Merkel cell carcinoma].

This review summarizes the current knowledge related to Merkel cell carcinoma and the first oncogenic human polyomvirus, the Merkel cell polyomavirus, to promote the clinical adaptation of the information.

Merkel Cell Carcinoma (Cutaneous Neuroendocrine Carcinoma)

The discovery of Merkel cell polyomavirus associated with MCC development is providing hope for the development of newer treatment methods, especially in immunocompromised individuals.

Multiple Primary Merkel Cell Carcinomas Presenting as Pruritic, Painful Lower Leg Tumors

This case represents an unusual presentation of primary MCC and demonstrates further evidence that radiation as monotherapy is an effective local treatment option for inoperable MCC.

Merkel cell carcinoma: what makes a difference?

The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma

  • K. AmberM. McLeodK. Nouri
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2013
The host's immune function appears to affect MCV's ability to cause cellular transformation leading to MCC, and an understanding of this virus may aid in future therapy options and current pathology protocols in diagnosing MCC.

Metastatic merkel cell carcinoma of the abdominal wall

A case of MCC is reported in an elderly male diagnosed and treated with chemotherapy and radiation, with a review of the literature of this rare malignancy.

An unusual case of diffuse Merkel cell carcinoma successfully treated with low dose radiotherapy

This work presents an unusual case of giant MCC‐positive MCPyV in a Greek woman located on the lower leg and her rapid and complete response to radiotherapy.



Merkel cell carcinoma – pathogenesis, clinical aspects and treatment

  • D. SchramaJ. C. Becker
  • Medicine, Biology
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2011
Recent findings of the pathogenesis of MCC are summarized, an overview of clinical aspects are presented and treatment options for MCCs are discussed.

Recent advances in the biology of Merkel cell carcinoma.

Immunohistochemical features of Merkel cell carcinoma in correlation with presence of Merkel cell polyomavirus DNA.

This is the first report analysing CK20, CK19, CD117 and ST3 protein expression of tumour cells as a function of presence of MCPyV DNA in a large cohort of MCC.

Management of Merkel tumours: an evidence-based review

Data from case series and meta-analyses of case series suggest that the addition of radiotherapy to surgery in patients with MCC can confer significant benefits with regard to reducing local and regional recurrence rates and prolonging disease-free survival.

Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma.

Although MCV-positive andMCV-negative MCCs may have different etiologies, these tumors have comparable clinical behaviors and prognosis.

Merkel cell carcinoma of skin-current controversies and recommendations

Physician judgment in individual cases of MCC is advisable, to balance the risk of recurrence versus the complications of treatment, and the benefit, if any, is not great from published studies so far.

Merkel cell carcinoma: prognosis and treatment of patients from a single institution.

The data demonstrate that the natural history of MCC is variable and dependent on the stage of disease at presentation, and pathologic nodal staging identifies a group of patients with excellent long-term survival.

Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors.

TO THE EDITOR Merkel cell carcinoma (MCC) is an increasingly common neuroendocrine cancer of the skin. MCC is an aggressive malignancy that is a significant cause of non-melanoma skin cancer

The etiology and epidemiology of merkel cell carcinoma.

Early aggressive treatment for Merkel cell carcinoma improves outcome.