Merkel cell carcinoma: histopathologic and prognostic features according to the immunohistochemical expression of Merkel cell polyomavirus large T antigen correlated with viral load.

@article{LerouxKozal2015MerkelCC,
  title={Merkel cell carcinoma: histopathologic and prognostic features according to the immunohistochemical expression of Merkel cell polyomavirus large T antigen correlated with viral load.},
  author={Val{\'e}rie Leroux-Kozal and Nicolas L{\'e}v{\^e}que and V{\'e}ronique Brodard and Candice Lesage and Oriane Dudez and Marc Makeieff and Lukshe Kanagaratnam and M. -D. Diebold},
  journal={Human pathology},
  year={2015},
  volume={46 3},
  pages={443-53}
}
Merkel cell carcinoma (MCC) is a neuroendocrine skin malignancy frequently associated with Merkel cell polyomavirus (MCPyV), which is suspected to be oncogenic. In a series of MCC patients, we compared clinical, histopathologic, and prognostic features according to the expression of viral large T antigen (LTA) correlated with viral load. We evaluated the LTA expression by immunohistochemistry using CM2B4 antibody and quantified viral load by real-time polymerase chain reaction. We analyzed… CONTINUE READING
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