Merkel cell carcinoma: a review of current advances.

  title={Merkel cell carcinoma: a review of current advances.},
  author={Frank Qian Zhan and Vathani Sharon Packianathan and Nathalie Charlotte Zeitouni},
  journal={Journal of the National Comprehensive Cancer Network : JNCCN},
  volume={7 3},
Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous malignancy of neuroendocrine origin. Its incidence has tripled over the past 15 years. This article reviews the recent advancement in diagnosis, discoveries in pathogenesis, and updates in management. The acronym, AEIOU, has been proposed to aid in clinical identification. In addition to cytokeratin 20, newer immunohistochemical stains (in particular thyroid transcription factor-1 and neurofilament protein) have proven to be… CONTINUE READING


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