Merkel Cell Carcinoma: Epidemiology, Target, and Therapy

@inproceedings{Hughes2014MerkelCC,
  title={Merkel Cell Carcinoma: Epidemiology, Target, and Therapy},
  author={Mathew Hughes and Matthew E. Hardee and Lynn A. Cornelius and Laura Hutchins and Jurgen C. Becker and Ling Gao},
  booktitle={Current dermatology reports},
  year={2014}
}
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin with a rising incidence. MCC has metastatic potential regardless the size of the primary tumor and a 5-year disease associated mortality rate is 46 %. Surgery and radiation are the mainstays of management for primary MCC. There is no evidence-based effective chemotherapy for recurrent or metastatic diseases to date. In-depth mechanistic studies in MCC have uncovered important cellular events and the association with a… CONTINUE READING
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