Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context

@article{Andr2015MergingCC,
  title={Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context},
  author={Sabine Andr{\'e} and Herbert Kaltner and Klaus Kayser and Paul V Murphy and Hans-Joachim Gabius},
  journal={Histochemistry and Cell Biology},
  year={2015},
  volume={145},
  pages={185-199}
}
Recognition of glycans by lectins leads to cell adhesion and growth regulation. The specificity and selectivity of this process are determined by carbohydrate structure (sequence and shape) and topology of its presentation. The synthesis of (neo)glycoconjugates with bi- to oligo-valency (glycoclusters) affords tools to delineate structure–activity relationships by blocking lectin binding to an artificial matrix, often a glycoprotein, or cultured cell lines. The drawback of these assays is that… CONTINUE READING

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In order to approach the natural context , we here introduce lectin histochemistry on fixed tissue sections to determine the susceptibility of binding of two plant lectins , i.e. , GSA - II and WGA , to a series of 10 glycoclusters .
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