Merging bioactivity with liquid chromatography-mass spectrometry-based chemometrics to identify minor immunomodulatory compounds from a Micronesian adaptogen, Phaleria nisidai.

Abstract

This study presents a strategy based on repeatable reversed-phase LC-TOF-MS methods and chemometric statistical tools, including untargeted PCA and supervised OPLS-DA models, to identify low-yielding compounds with potent immunostimulant activity in Phaleria nisidai (Thymelaeaceae), a plant with a history of use as an adaptogen on the islands of Palau in… (More)
DOI: 10.1016/j.chroma.2014.08.049

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Cite this paper

@article{Kulakowski2014MergingBW, title={Merging bioactivity with liquid chromatography-mass spectrometry-based chemometrics to identify minor immunomodulatory compounds from a Micronesian adaptogen, Phaleria nisidai.}, author={Daniel M Kulakowski and Shi-Biao Wu and Michael J. Balick and Edward J. Kennelly}, journal={Journal of chromatography. A}, year={2014}, volume={1364}, pages={74-82} }