Merg1a K+ channel induces skeletal muscle atrophy by activating the ubiquitin proteasome pathway.

@article{Wang2006Merg1aKC,
  title={Merg1a K+ channel induces skeletal muscle atrophy by activating the ubiquitin proteasome pathway.},
  author={Xun Wang and Gregory H Hockerman and Henry W Green and Charles F. Babbs and Sulma I Mohammad and David Gerrard and Mickey A. Latour and Barry London and Kevin M Hannon and Amber L. Pond},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 9},
  pages={
          1531-3
        }
}
Skeletal muscle atrophy results from an imbalance in protein degradation and protein synthesis and occurs in response to injury, various disease states, disuse, and normal aging. Current treatments for this debilitating condition are inadequate. More information about mechanisms involved in the onset and progression of muscle atrophy is necessary for development of more effective therapies. Here we show that expression of the mouse ether-a-go-go related gene (Merg1a) K+ channel is up-regulated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

Muscle catabolic mechanisms:from disuse atrophy to cachexia.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Targeted deletion of Kcne3 impairs skeletal muscle function in mice.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Ectopic expression of IGF-I and Shh by skeletal muscle inhibits disuse-mediated skeletal muscle atrophy and bone osteopenia in vivo.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2003
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Molecular signaling pathways regulating muscle proteolysis during atrophy.

  • Current opinion in clinical nutrition and metabolic care
  • 2005
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Dominant-negative subunits reveal potassium channel families that contribute to M-like potassium currents.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2002
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL