Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase

@article{Park2013MercuryIT,
  title={Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase},
  author={Hye-jeong Park and Hyung-Sun Youn},
  journal={Toxicology and Industrial Health},
  year={2013},
  volume={29},
  pages={169 - 174}
}
Nuclear factor-κB (NF-κB) is a transcription factor that mediates the inducible expression of a variety of genes involved in immune and inflammatory responses. NF-κB activation induces numerous proinflammatory gene products including cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). The divalent heavy metal mercury has been used for thousands of years. Although mercury is clearly toxic to most mammalian organ systems, especially the immune system, exposure has… 

Figures from this paper

Aster yomena suppresses LPS-induced cyclooxygenase-2 and inducible nitric oxide synthase expression
TLDR
The results suggest that A. yomena extract has the potential to be developed as a potent anti-inflammatory drug.
Aster yomena suppresses LPS-induced cyclooxygenase-2 and inducible nitric oxide synthase expression
TLDR
Results suggest that A. yomena extract (EAY) has the potential to be developed as a potent anti-inflammatory drug.
Mercury exposure induces proinflammatory enzymes in vascular fibroblasts.
Pro-inflammatory effects of metals in persons and animals exposed to tobacco smoke.
Modulation of Vasodilator Response via the Nitric Oxide Pathway after Acute Methyl Mercury Chloride Exposure in Rats
TLDR
An increase in the vascular reactivity to ACh in aorta of rats acutely exposed to methyl mercury chloride is demonstrated, demonstrating the involvement of NO and not of endothelium-derived hyperpolarizing factor (EDHF).
Retracted Article: Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages
TLDR
The results show that [cyclo-Leu-His-Thr]∼LCP-3 has potent anti-inflammatory potency in RAW264.7 and HMC-1 cells under LPS (lipopolysaccharide) stimuli and mechanistic studies show that LCP-3 attenuates pro-inflammatory cytokine expression.
The neuroprotective effect of berberine in mercury-induced neurotoxicity in rats
TLDR
Berberine augments antioxidant defense with anti-inflammatory and anti-apoptotic activities against HgCl2-induced neurotoxicity and provides evidence that it has a therapeutic potential as neuroprotective agent.
...
1
2
3
...

References

SHOWING 1-10 OF 33 REFERENCES
Targeting NOX, INOS and COX‐2 in inflammatory cells: Chemoprevention using food phytochemicals
TLDR
The cancer preventive potentials of several food phytochemicals targeting the induction of NOX, iNOS and COX‐2 are described.
Inducible nitric oxide synthase expression in mercury chloride-induced acute tubular necrosis.
TLDR
Observations indicate that the induction of iNOS may play a role in the progression of HgCl2-induced ATN through the exacerbation of proximal tubule epithelial cell damage.
Cyclooxygenase-2: a therapeutic target.
TLDR
Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both enzymes, and a new class of COX-2 selective inhibitors (COXIBs) preferentially inhibit the COx-2 enzyme.
Mercuric ion attenuates nuclear factor-kappaB activation and DNA binding in normal rat kidney epithelial cells: implications for mercury-induced nephrotoxicity.
TLDR
Hg(2+), at low cellular concentrations, attenuates NF-kappaB activation at sites associated with IkappaBalpha phosphorylation and degradation, nuclear translocation of the p50p65 heterodimer, and association of p50-cys(62) with the DNA kappaB binding site.
Cyclooxygenases 1 and 2.
TLDR
The discovery ofCOX-2 has made possible the design of drugs that reduce inflammation without removing the protective PGs in the stomach and kidney made by COX-1, which may not only be anti-inflammatory but may also be active in colon cancer and Alzheimer's disease.
Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS.
  • M. Hori, M. Kita, H. Karaki
  • Biology, Medicine
    American journal of physiology. Gastrointestinal and liver physiology
  • 2001
TLDR
Findings show that LPS increases iNOS expression and stimulates NO production in muscularis resident macrophages to inhibit smooth muscle contraction.
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
▪ Abstract The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it
Inhibition of homodimerization of Toll-like receptor 4 by curcumin.
Cadmium and mercury cause an oxidative stress-induced endothelial dysfunction
TLDR
While high concentrations of heavy metals are cytotoxic, lower concentration induce a compensatory protective response, which may explain threshold effects in metal-ion toxicity.
...
1
2
3
4
...