Mercury-induced apoptosis in human lymphocytes: caspase activation is linked to redox status.

@article{Shenker2002MercuryinducedAI,
  title={Mercury-induced apoptosis in human lymphocytes: caspase activation is linked to redox status.},
  author={Bruce J. Shenker and Lisa Pankoski and Ali Zekavat and Irving Milton Shapiro},
  journal={Antioxidants & redox signaling},
  year={2002},
  volume={4 3},
  pages={
          379-89
        }
}
There is growing evidence that heavy metals, in general, and mercurial compounds, in particular, are toxic to the human immune system. We have previously shown that methyl mercuric chloride (MeHgCl) is a potent human T-cell apoptogen; moreover, mitochondria appear to be a target organelle for the induction of cell death. The objective of this study was to determine the impact of MeHgCl on mitochondrial function in lymphocytes in terms of modulating reactive oxygen species (ROS) generation… CONTINUE READING
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