Mercury binding site on Na+/K(+)-ATPase: a cysteine in the first transmembrane segment.

@article{Wang1996MercuryBS,
  title={Mercury binding site on Na+/K(+)-ATPase: a cysteine in the first transmembrane segment.},
  author={Xueren Wang and J. D. Horisberger},
  journal={Molecular pharmacology},
  year={1996},
  volume={50 3},
  pages={
          687-91
        }
}
Mercury is an element of great pharmacological and toxicological importance. It reacts with sulfhydryl groups on proteins to form mercaptides. Mercuric mercury (Hg2+), a form that shows primarily epithelial toxicity, can inhibit Na+/K(+)-ATPase at low concentration, but its molecular target site on the protein is not known. To investigate the interaction of Hg2+ with Na+/K(+)-ATPase, we studied the inhibition of Na+/K+ pump activity by inorganic mercury (HgCl2) in Xenopus laevis oocytes… CONTINUE READING

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