Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells.

@article{ChinChan2015MercuryRT,
  title={Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells.},
  author={Miguel Chin-Chan and Jos{\'e} Segovia and Liliana Quintanar and Trinidad Arcos-L{\'o}pez and Louis B. Hersh and K. Martin Chow and David W. Rodgers and Betzabet Quintanilla-Vega},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2015},
  volume={145 1},
  pages={
          128-37
        }
}
Levels of amyloid beta (Aβ) in the central nervous system are regulated by the balance between its synthesis and degradation. Neprilysin (NEP) is associated with Alzheimer's disease (AD) by its ability to degrade Aβ. Some studies have involved the exposure to mercury (Hg) in AD pathogenesis; therefore, our aim was to investigate the effects on the anabolism and catabolism of Aβ in differentiated SH-SY5Y cells incubated with 1-20 μM of Hg. Exposure to 20 µM of Hg induced an increase in Aβ-42… CONTINUE READING
BETA

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Amyloid precursor protein trafficking, processing, and function.

  • The Journal of biological chemistry
  • 2008
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Effects of lead exposure on the expression of amyloid β and phosphorylated tau proteins in the C57BL/6 mouse hippocampus at different life stages.

Fangli Liu, Zhenfei Xue, +5 authors Wenjie Li
  • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2014
VIEW 2 EXCERPTS

Similar Papers

Loading similar papers…