Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity.

@article{Zak2012MerckAI,
  title={Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity.},
  author={Daniel E. Zak and Erica Andersen-Nissen and Eric R. Peterson and Alicia H. Sato and M Kristina Hamilton and Joleen Borgerding and Akshay T. Krishnamurty and Joanne T. Chang and Devin J. Adams and Tiffany R Hensley and Alexander I. Salter and Cecilia Morgan and Ann C Duerr and Stephen C. De Rosa and Alan Aderem and M Juliana McElrath},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 50},
  pages={E3503-12}
}
To better understand how innate immune responses to vaccination can lead to lasting protective immunity, we used a systems approach to define immune signatures in humans over 1 wk following MRKAd5/HIV vaccination that predicted subsequent HIV-specific T-cell responses. Within 24 h, striking increases in peripheral blood mononuclear cell gene expression associated with inflammation, IFN response, and myeloid cell trafficking occurred, and lymphocyte-specific transcripts decreased. These… CONTINUE READING