MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.

@article{Cai2016MerTKCL,
  title={MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.},
  author={Bishuang Cai and Edward B Thorp and Amanda C. Doran and Manikandan Subramanian and Brian E. Sansbury and Chyuan-Sheng Lin and Matthew R. Spite and Gabrielle Fredman and I ra Tabas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 23},
  pages={6526-31}
}
The acute inflammatory response requires a coordinated resolution program to prevent excessive inflammation, repair collateral damage, and restore tissue homeostasis, and failure of this response contributes to the pathology of numerous chronic inflammatory diseases. Resolution is mediated in part by long-chain fatty acid-derived lipid mediators called specialized proresolving mediators (SPMs). However, how SPMs are regulated during the inflammatory response, and how this process goes awry in… CONTINUE READING
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