MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells.

@article{Healy2016MerTKIA,
  title={MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells.},
  author={Luke M Healy and Gabrielle Perron and So-Yoon Won and Mackenzie A Michell-Robinson and Ayman Rezk and Samuel K. Ludwin and Craig S Moore and Jeffery A. Hall and Amit Bar-Or and Jack P. Antel},
  journal={Journal of immunology},
  year={2016},
  volume={196 8},
  pages={
          3375-84
        }
}
Multifocal inflammatory lesions featuring destruction of lipid-rich myelin are pathologic hallmarks of multiple sclerosis. Lesion activity is assessed by the extent and composition of myelin uptake by myeloid cells present in such lesions. In the inflamed CNS, myeloid cells are comprised of brain-resident microglia, an endogenous cell population, and monocyte-derived macrophages, which infiltrate from the systemic compartment. Using microglia isolated from the adult human brain, we demonstrate… CONTINUE READING

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