Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS).

@article{Krause2015MerTK,
  title={Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS).},
  author={Sarah Krause and Christian Pfeiffer and Susanne Strube and Ameera Alsadeq and Henning Fedders and Christian Vokuhl and Sonja Loges and Jonas S. Waizenegger and Isabel Ben-Batalla and Gunnar Cario and Anja Moericke and Martin Stanulla and Martin Schrappe and Denis Martin Schewe},
  journal={Blood},
  year={2015},
  volume={125 5},
  pages={820-30}
}
Patients with t(1;19)-positive acute lymphoblastic leukemia (ALL) are prone to central nervous system (CNS) relapses, and expression of the TAM (Tyro3, Axl, and Mer) receptor Mer is upregulated in these leukemias. We examined the functional role of Mer in the CNS in preclinical models and performed correlative studies in 64 t(1;19)-positive and 93 control pediatric ALL patients. ALL cells were analyzed in coculture with human glioma cells and normal rat astrocytes: CNS coculture caused… CONTINUE READING
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