Meptazinol

@article{Holmes1983Meptazinol,
  title={Meptazinol},
  author={B. Holmes and Alan Ward},
  journal={Drugs},
  year={1983},
  volume={30},
  pages={285-312}
}
SummarySynopsis: Meptazinol1 is a new opioid-type analgesic with mixed agonist/antagonist properties. It may be given orally, intravenously or intramuscularly. In studies in patients with moderate to severe pain of various aetiologies, usually following surgery or in obstetrics, the characteristics of analgesia with meptazinol were comparable to those seen with equianalgesic doses of pentazocine, pethidine or a combination of dextropropoxyphene and paracetamol. Preoperative use and use as a… 

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TLDR
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TLDR
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References

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TLDR
In a single-blind study of a new hexahydroazepine analgesic, meptazinol, intramuscular doses of 50-100 mg produced effective, dose-related analgesia in 45 patients recovering from abdominal surgery, with good correlation between pain relief assessed by the patient, by the physician and indirectly by pulmonary function tests.

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Nalbuphine appears to offer a useful alternative to morphine in patients with moderate to severe pain, and it appears to produce satisfactory anaesthesia when used as a component of a 'balanced' anaesthesia technique, although a relatively low 'ceiling' effect for reduction of anaesthetic requirements with nal Buphine may limit its usefulness in this regard.

Preliminary clinical and pharmacokinetic experiences in the newborn when meptazinol is compared with pethidine as an obstetric analgesic.

TLDR
The results of the trial suggest that meptazinol may have less depressant effects on the newborn, and may be preferable to pethidine as an obstetric analgesic.

Clinical evaluation of meptazinol. a new analgesic, in postoperative pain.

TLDR
There was a good correlation between pain relief assessed by the patient, by the physician, and indirectly by pulmonary function tests and the only side-effect was vomiting in a few patients receiving multiple doses of the drug.

Clinical review of parenteral meptazinol.

TLDR
Meptazinol is a centrally acting drug which produces analgesia of comparable intensity to the opiates, but there is evidence that this is more rapid in onset and of shorter duration.

A Trial of Meptazinol for the Relief of Pain after Abdominal Surgery

TLDR
The drug is of particular interest in that the clinical impression of minimal ventilatory depression has been confirmed, 3 60 mg meptazinol showing less ventilatories depression than 10 mg of morphine.

Effects of graded oral doses of meptazinol and pentazocine in comparison with placebo on experimentally induced pain in healthy humans.

TLDR
Investigation of the effects of single oral doses of meptazinol 100, 200, and 400 mg in comparison with pentazocine 50 and 100 mg and with placebo on experimentally induced pain gives further evidence that meptazerinol is well suited to replace other opioid analgesics compromised by a high incidence of adverse effects.

Effect of antidysrhythmic and analgesic drugs on haemodynamics and fibrillatory threshold.

  • S. Rashid
  • Biology, Medicine
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  • 1981
TLDR
Pentazocine was shown to possess the best antidysrhythmic profile against electrically-induced ventricular fibrillation and the analgesics pentzaocine, pethidine and meptazinol, unlike morphine, were effective in raising the V.F.T. at doses causing minimal disturbance of cardiovascular dynamics in this experimental model.

Analgesia after operation. A controlled comparison of meptazinol, pentazocine and pethidine.

In a double-blind investigation of the efficacy on pain following abdominal or orthopaedic surgery, meptazinol 100 mg, a new hexahydroazepine derivative, was found to be equipotent with pentazocine

A comparison of the respiratory effects of meptazinol, pentazocine and morphine.

The respiratory effects of a new strong analgesic, meptazinol, were compared with a placebo and with equianalgesic doses of morphine and pentazocine in a double-blind crossover trial in seven healthy
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