author={B. Holmes and Alan Ward},
SummarySynopsis: Meptazinol1 is a new opioid-type analgesic with mixed agonist/antagonist properties. It may be given orally, intravenously or intramuscularly. In studies in patients with moderate to severe pain of various aetiologies, usually following surgery or in obstetrics, the characteristics of analgesia with meptazinol were comparable to those seen with equianalgesic doses of pentazocine, pethidine or a combination of dextropropoxyphene and paracetamol. Preoperative use and use as a… 

Dezocine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.

Preliminary pharmacodynamic data indicate that the ceiling of analgesic activity of dezocine occurs at a higher level of analgesia than that of reference agonist/antagonist agents, and the drug exhibited a morphine-like degree of anaesthetic-sparing activity in animals.

Meptazinol and ethanol: a fatal intoxication.

A death due to the combined effects of meptazinol and alcohol in a man with significant heart disease and alcoholic liver disease is reported, with atherosclerotic coronary artery disease as a contributing factor.

Meptazinol and pentazocine: effects on prolactin, growth hormone and vasopressin levels in plasma.

It was concluded that the augmented AVP release following meptazinol administration was likely to be a non-specific response induced by nausea and not an effect mediated by opiate receptors.

Meptazinol and pentazocine: plasma catecholamines and other effects in healthy volunteers.

The effects of meptazinol in healthy volunteers do not differ markedly from those of pentazocine, although it may cause more nausea and dysphoria, and the pronounced increase in plasma adrenaline concentrations in two of six subjects calls for caution in its use in patients with cardiac diseases.

Current Guidelines for the Treatment of Acute Pain in Children

Premature and full-term neonates, infants and children are capable of experiencing pain just like adults, and deserve aggressive treatment, including opioids and nonopioid analgesics.

Parecoxib sodium has opioid-sparing effects in patients undergoing total knee arthroplasty under spinal anaesthesia.

Parecoxib sodium provides opioid-sparing analgesic effects in postoperative patients after routine total knee replacement surgery, and a reduction in opioid-type side-effects was not demonstrated in the pare Coxib sodium groups.

Structural comparisons of meptazinol with opioid analgesics

Meptazionol should have a different mechanism of action to known analgesics, which would be helpful in further investigations of meptazional in the search for non-addictive analgesics.



Intramuscular meptazinol analgesia after surgery: a study of the dose-response effect and a controlled comparison with pentazocine and pethidine.

In a single-blind study of a new hexahydroazepine analgesic, meptazinol, intramuscular doses of 50-100 mg produced effective, dose-related analgesia in 45 patients recovering from abdominal surgery, with good correlation between pain relief assessed by the patient, by the physician and indirectly by pulmonary function tests.

Nalbuphine. A preliminary review of its pharmacological properties and therapeutic efficacy.

Nalbuphine appears to offer a useful alternative to morphine in patients with moderate to severe pain, and it appears to produce satisfactory anaesthesia when used as a component of a 'balanced' anaesthesia technique, although a relatively low 'ceiling' effect for reduction of anaesthetic requirements with nal Buphine may limit its usefulness in this regard.

Preliminary clinical and pharmacokinetic experiences in the newborn when meptazinol is compared with pethidine as an obstetric analgesic.

The results of the trial suggest that meptazinol may have less depressant effects on the newborn, and may be preferable to pethidine as an obstetric analgesic.

Clinical evaluation of meptazinol. a new analgesic, in postoperative pain.

There was a good correlation between pain relief assessed by the patient, by the physician, and indirectly by pulmonary function tests and the only side-effect was vomiting in a few patients receiving multiple doses of the drug.

Clinical review of parenteral meptazinol.

Meptazinol is a centrally acting drug which produces analgesia of comparable intensity to the opiates, but there is evidence that this is more rapid in onset and of shorter duration.

A Trial of Meptazinol for the Relief of Pain after Abdominal Surgery

The drug is of particular interest in that the clinical impression of minimal ventilatory depression has been confirmed, 3 60 mg meptazinol showing less ventilatories depression than 10 mg of morphine.

Effects of graded oral doses of meptazinol and pentazocine in comparison with placebo on experimentally induced pain in healthy humans.

Investigation of the effects of single oral doses of meptazinol 100, 200, and 400 mg in comparison with pentazocine 50 and 100 mg and with placebo on experimentally induced pain gives further evidence that meptazerinol is well suited to replace other opioid analgesics compromised by a high incidence of adverse effects.

Effect of antidysrhythmic and analgesic drugs on haemodynamics and fibrillatory threshold.

  • S. Rashid
  • Biology, Medicine
    JPMA. The Journal of the Pakistan Medical Association
  • 1981
Pentazocine was shown to possess the best antidysrhythmic profile against electrically-induced ventricular fibrillation and the analgesics pentzaocine, pethidine and meptazinol, unlike morphine, were effective in raising the V.F.T. at doses causing minimal disturbance of cardiovascular dynamics in this experimental model.

Analgesia after operation. A controlled comparison of meptazinol, pentazocine and pethidine.

In a double-blind investigation of the efficacy on pain following abdominal or orthopaedic surgery, meptazinol 100 mg, a new hexahydroazepine derivative, was found to be equipotent with pentazocine

A comparison of the respiratory effects of meptazinol, pentazocine and morphine.

The respiratory effects of a new strong analgesic, meptazinol, were compared with a placebo and with equianalgesic doses of morphine and pentazocine in a double-blind crossover trial in seven healthy