Mepolizumab and exacerbations of refractory eosinophilic asthma.

  title={Mepolizumab and exacerbations of refractory eosinophilic asthma.},
  author={Pranabashis Haldar and Christopher Brightling and Beverley Hargadon and Sumit Gupta and William R Monteiro and Ana S{\'a} Sousa and Richard P Marshall and Peter Bradding and Ruth H. Green and Andrew J. Wardlaw and Ian D. Pavord},
  journal={The New England journal of medicine},
  volume={360 10},
BACKGROUND Exacerbations of asthma are associated with substantial morbidity and mortality and with considerable use of health care resources. Preventing exacerbations remains an important goal of therapy. There is evidence that eosinophilic inflammation of the airway is associated with the risk of exacerbations. METHODS We conducted a randomized, double-blind, placebo-controlled, parallel-group study of 61 subjects who had refractory eosinophilic asthma and a history of recurrent severe… CONTINUE READING
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