Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma.

@article{Kelly2017MepolizumabAA,
  title={Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma.},
  author={Elizabeth A Kelly and Stephane Esnault and Lin Ying Liu and Michael D Evans and Mats W Johansson and Sameer Mathur and Deane F Mosher and Loren Clark Denlinger and Nizar N Jarjour},
  journal={American journal of respiratory and critical care medicine},
  year={2017},
  volume={196 11},
  pages={1385-1395}
}
RATIONALE Mepolizumab, an IL-5-blocking antibody, reduces exacerbations in patients with severe eosinophilic asthma. Mepolizumab arrests eosinophil maturation; however, the functional phenotype of eosinophils that persist in the blood and airway after administration of IL-5 neutralizing antibodies has not been reported. OBJECTIVES To determine the effect of anti-IL-5 antibody on the numbers and phenotypes of allergen-induced circulating and airway eosinophils. METHODS Airway inflammation… CONTINUE READING
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