Mepirizole-induced duodenal ulcers in rats and their pathogenesis

@article{Okabe1982MepirizoleinducedDU,
  title={Mepirizole-induced duodenal ulcers in rats and their pathogenesis},
  author={Dr. Susumu Okabe and MA YasunobuIshihara and BS HirokazuInoo and MA HiroshiTanaka},
  journal={Digestive Diseases and Sciences},
  year={1982},
  volume={27},
  pages={242-249}
}
Duodenal ulcers were produced in rats following either an oral or parenteral administration of 200 mg/kg of mepirizole, a nonsteroidal antiinflammatory agent. Deep ulcers, including perforated ones, were induced in the proximal duodenum with an incidence of over 90%. Mortality due to perforation was less than 5%. The agent also induced several erosions in the antrum. Feeding of animals after the ingestion of mepirizole markedly suppressed the development of both duodenal ulcers and gastric… CONTINUE READING
15 Citations
20 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Effect of N-acetyl-Lglutamine aluminum complex (KW-ll0) on experimental duodenal ulcers in rats

  • H Tanaka, K Shuto, H Marumo
  • Pharmacometrics 20:185-i93,
  • 1980
2 Excerpts

Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins

  • B JRWhittle
  • Eur J Pharmacol
  • 1976
1 Excerpt

Similar Papers

Loading similar papers…