Mepirizole-induced duodenal ulcers in rats and their pathogenesis

  title={Mepirizole-induced duodenal ulcers in rats and their pathogenesis},
  author={Dr. Susumu Okabe and MA YasunobuIshihara and BS HirokazuInoo and MA HiroshiTanaka},
  journal={Digestive Diseases and Sciences},
Duodenal ulcers were produced in rats following either an oral or parenteral administration of 200 mg/kg of mepirizole, a nonsteroidal antiinflammatory agent. Deep ulcers, including perforated ones, were induced in the proximal duodenum with an incidence of over 90%. Mortality due to perforation was less than 5%. The agent also induced several erosions in the antrum. Feeding of animals after the ingestion of mepirizole markedly suppressed the development of both duodenal ulcers and gastric… CONTINUE READING
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